Windows 10 loss of TCP connectivity

EventID 4227 seems related to too many outstanding TCP connections.

Not an answer, but the following first steps are too long for a comment:

1. Run sfc /scannow
2. In Device Manager delete the network adapter and reboot
3. Use TCPView to see outgoing connections when this happens
4. Increase maximum of outgoing connections by setting TcpNumConnections and see also the other parameters described in this article
5. Disable IPv6
6. Restart Chrome
7. Start Windows in Safe mode with network and if this stops happening then some installed application is to blame
8. Use Chrome in incognito mode to temporarily disable extensions
9. Try Firefox
10. Do you have many tabs open? Or when this is happening do you always have one particular website open?

The results of the above may help with localizing the problem.

Try to stop and disable "IP Helper" service and disable(uncheck) in property of adapter IPv6 protocol.