Area in KM from Polygon of coordinates

It wasn't readily apparent to me how to use @sgillies answer, so here is a more verbose version:

import pyproj    
import shapely
import shapely.ops as ops
from shapely.geometry.polygon import Polygon
from functools import partial


geom = Polygon([(0, 0), (0, 10), (10, 10), (10, 0), (0, 0)])
geom_area = ops.transform(
    partial(
        pyproj.transform,
        pyproj.Proj(init='EPSG:4326'),
        pyproj.Proj(
            proj='aea',
            lat1=geom.bounds[1],
            lat2=geom.bounds[3])),
    geom)

# Print the area in m^2
print geom_area.area 

It looks like your coordinates are longitude and latitude, yes? Use Shapely's shapely.ops.transform function to transform the polygon to projected equal area coordinates and then take the area.

python
import pyproj
from functools import partial

geom_aea = transform(
partial(
    pyproj.transform,
    pyproj.Proj(init='EPSG:4326'),
    pyproj.Proj(
        proj='aea',
        lat1=geom.bounds[1],
        lat2=geom.bounds[3])),
geom)

print(geom_aea.area)
# Output in m^2: 1083461.9234313113 

The above answers seem to be correct, EXCEPT that at some point recently, the lat1 and lat2 parameters in the pyproj code were renamed with underscores: lat_1 and lat_2 (see https://stackoverflow.com/a/55259718/1538758). I don't have enough rep to comment, so I'm making a new answer (sorry not sorry)

import pyproj    
import shapely
import shapely.ops as ops
from shapely.geometry.polygon import Polygon
from functools import partial


geom = Polygon([(0, 0), (0, 10), (10, 10), (10, 0), (0, 0)])
geom_area = ops.transform(
    partial(
        pyproj.transform,
        pyproj.Proj(init='EPSG:4326'),
        pyproj.Proj(
            proj='aea',
            lat_1=geom.bounds[1],
            lat_2=geom.bounds[3])),
    geom)

# Print the area in m^2
print geom_area.area