Arranging widgets in ipywidgets interactive

interactive is restricted to fairly simple widget layouts. Have a look at the Flexbox options if you want to customize them some more.

One simple get around is to use the interactive call to generate and link your widgets and functions, then restructure the widgets inside a HBox. Then add a layout that tells the box to wrap at line ends. I added a couple more imports and three lines at the end to achieve this.

1) controls - an HBox of your input widgets.

2) The Output widget generated by the interactive call.

3) A VBox that wraps the two together.

import matplotlib.pyplot as plt
import numpy as np
import pandas as pd
plt.style.use('seaborn')
%config InlineBackend.figure_format = 'svg'
#importing the necessary items from the Ipywidgets library 
from ipywidgets import interactive,interact, HBox, Layout,VBox
#function to plot the different curves
def plot_function(u=1,v=2,w=3,x=4,y=5,z=6):
    time=np.arange(0,1,0.01)
    df=pd.DataFrame({"Y1":np.sin(time*u*2*np.pi),"y2":np.sin(time*v*2*np.pi),"y3":np.sin(time*w*2*np.pi),
                    "y4":np.sin(time*x*2*np.pi),"y5":np.sin(time*y*2*np.pi),"y6":np.sin(time*z*2*np.pi)})
    df.plot()
widget=interactive(plot_function,u=1,v=2,w=3,x=4,y=5,z=6)
controls = HBox(widget.children[:-1], layout = Layout(flex_flow='row wrap'))
output = widget.children[-1]
display(VBox([controls, output]))