How to create word docs programmatically from a template

Don't use Office Automation. Office automation opens up an instance of office in the background and performs the actions on it. Opening up an office instance 600 times doesn't seem like a very interesting thing to do. (and it would never run serverside)

Take a look at Open XML. You can find loads about it below:

http://openxmldeveloper.org/

edit: Openxmldeveloper is shutting down. Find all the sources mentioned above at http://www.ericwhite.com/ instead.

Maybe you should be looking at Microsoft.Office.Tools.Word.Document?

Document.SelectContentControlsByTitle