Is it possible to have autocomplete in a notebook in Google Colab?

Yup. Press control space (or command space, on a Mac) and autocomplete suggestions will appear.

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I'm on a macbook pro, Option+ Esc performs autocomplete for me.

Press Ctrl + space for Mac, as well as for Windows.
Works like magic, see the image below:

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If you navigate to Settings... and then uncheck "Automatically trigger code completions":

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...you'll then be able to use tab-to-complete like in a conventional Jupyter notebook. From the Keyboard Shortcuts page of the Colaboratory app:

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