Remove old AndroidStudio Cache folders - OSX

It does not need this. You just delete the cache once on the new version. Of course, if you do not see it, there's no problem.

Choose File | Invalidate Caches/Restart.

It's safe generally,

The cache in /System/Library/Caches is useful for system but the cache in ~/Library/Caches are not that useful.

Deleting everything at once is not recommended. But if you want to delete specific file remove it manually