split string only on first instance of specified character

I avoid RegExp at all costs. Here is another thing you can do:

"good_luck_buddy".split('_').slice(1).join('_')

Use capturing parentheses:

'good_luck_buddy'.split(/_(.*)/s)
['good', 'luck_buddy', ''] // ignore the third element

They are defined as

If separator contains capturing parentheses, matched results are returned in the array.

So in this case we want to split at _.* (i.e. split separator being a sub string starting with _) but also let the result contain some part of our separator (i.e. everything after _).

In this example our separator (matching _(.*)) is _luck_buddy and the captured group (within the separator) is lucky_buddy. Without the capturing parenthesis the luck_buddy (matching .*) would've not been included in the result array as it is the case with simple split that separators are not included in the result.

We use the s regex flag to make . match on newline (\n) characters as well, otherwise it would only split to the first newline.

What do you need regular expressions and arrays for?

myString = myString.substring(myString.indexOf('_')+1)

var myString= "hello_there_how_are_you"
myString = myString.substring(myString.indexOf('_')+1)
console.log(myString)