SQLite add Primary Key

As long as you are using CREATE TABLE, if you are creating the primary key on a single field, you can use:

CREATE TABLE mytable (
field1 TEXT,
field2 INTEGER PRIMARY KEY,
field3 BLOB,
);

With CREATE TABLE, you can also always use the following approach to create a primary key on one or multiple fields:

CREATE TABLE mytable (
field1 TEXT,
field2 INTEGER,
field3 BLOB,
PRIMARY KEY (field2, field1)
);

Reference: http://www.sqlite.org/lang_createtable.html

This answer does not address table alteration.

You can't modify SQLite tables in any significant way after they have been created. The accepted suggested solution is to create a new table with the correct requirements and copy your data into it, then drop the old table.

here is the official documentation about this: http://sqlite.org/faq.html#q11