Tell if Python is in interactive mode

sys.ps1 and sys.ps2 are only defined in interactive mode.

__main__.__file__ doesn't exist in the interactive interpreter:

import __main__ as main
print hasattr(main, '__file__')

This also goes for code run via python -c, but not python -m.

Use sys.flags:

if sys.flags.interactive:
    #interactive
else:
    #not interactive

I compared all the methods I found and made a table of results. The best one seems to be this:

hasattr(sys, 'ps1')

enter image description here

If anyone has other scenarios that might differ, comment and I'll add it

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