What's the difference between performSelectorOnMainThread: and dispatch_async() on main queue?

By default, -performSelectorOnMainThread:withObject:waitUntilDone: only schedules the selector to run in the default run loop mode. If the run loop is in another mode (e.g. the tracking mode), it won't run until the run loop switches back to the default mode. You can get around this with the variant -performSelectorOnMainThread:withObject:waitUntilDone:modes: (by passing all the modes you want it to run in).

On the other hand, dispatch_async(dispatch_get_main_queue(), ^{ ... }) will run the block as soon as the main run loop returns control flow back to the event loop. It doesn't care about modes. So if you don't want to care about modes either, dispatch_async() may be the better way to go.

It's likely because performSelectorOnMainThread:withObject:waitUntilDone: queues the message with common run loop modes. According to Apple's Concurrency Programming Guide, the main queue will interleave queued tasks with other events from the app's run loop. Thus, if there are other events to be processed in the event queue, the queued blocks in the dispatch queue may be run first, even though they were submitted later.

This article is a superb explanation to performSelectorOnMainThread vs. dispatch_async, which also answers the above question.