Estimates on number of topologies on a finite set
See The number of finite topologies by Kleitman and Rothschild. If $T_n$ is the number of topologies on a set with $n$ elements, they show that $$\log_2 T_n\sim n^2/4$$ This is quite an old paper and there may be a better asymptotic formula at this point. Asymptotically, the logarithm of the number of topologies is also equal to the logarithm of the number of partial orders on the set. The same authors have a sequel to the paper that gives a better formula for the number of partial orders, but without the logarithm I believe they cease to be asymptotically equal.
On a finite set $S$, the topology is uniquely determined by the closures of singletons: A subset of $S$ is closed iff it contains the closure of all its elements. Given a topology, we can define $$\tag1a\le b\iff \overline{\{a\}}\subseteq \overline{\{b\}}$$ (or equivalently, $a\in \overline{\{b\}}$). This need not be a partial order because we can have $a\le b$ and $b\le a$ with $a\ne b$. But it is a reflexive and transitive relation on $S$.
On the other hand, from a a reflexive and transitive relation $\le$ on $S$, we can define a topology by declaring $$\tag2 A\text{ closed}\iff\forall a\in A\colon \forall x\in S\colon x\le a\to x\in A.$$ One verifies that the union or intersection of two closed sets is closed and trivially $\emptyset$ and $S$ are closed.
Moreover, the associations topology $\leftrightarrow$ reflexive transitive relation in $(1)$ and $(2)$ are inverse of each other, hence
On a finite set, there are as many topologies as there are reflexive transitive binary relations.
The relation to partial orders is that a reflexive transitive binary relation on $S$ is the same as a partial order on a partition of $S$. In particular, if the counts of topologies and partial orders are $T_n$ and $P_n$, respectively, we have $$ T_n=P_n+{n\choose 2}P_{n-1}+\left({n\choose 3}+\frac12{n\choose 2}{n-2\choose 2}\right)P_{n-2}+\ldots+2^{n-1}P_2+P_1.$$