How can you dynamically create variables via a while loop?

Unless there is an overwhelming need to create a mess of variable names, I would just use a dictionary, where you can dynamically create the key names and associate a value to each.

a = {}
k = 0
while k < 10:
    <dynamically create key> 
    key = ...
    <calculate value> 
    value = ...
    a[key] = value 
    k += 1

There are also some interesting data structures in the new 'collections' module that might be applicable:

http://docs.python.org/dev/library/collections.html

playing with globals() makes it possible:

import random

alphabet = tuple('abcdefghijklmnopqrstuvwxyz')


print '\n'.join(repr(u) for u in globals() if not u.startswith('__'))

for i in xrange(8):
    globals()[''.join(random.sample(alphabet,random.randint(3,26)))] = random.choice(alphabet)

print

print '\n'.join(repr((u,globals()[u])) for u in globals() if not u.startswith('__'))

one result:

'alphabet'
'random'

('hadmgoixzkcptsbwjfyrelvnqu', 'h')
('nzklv', 'o')
('alphabet', ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j', 'k', 'l', 'm', 'n', 'o', 'p', 'q', 'r', 's', 't', 'u', 'v', 'w', 'x', 'y', 'z'))
('random', <module 'random' from 'G:\Python27\lib\random.pyc'>)
('ckpnwqguzyslmjveotxfbadh', 'f')
('i', 7)
('xwbujzkicyd', 'j')
('isjckyngxvaofdbeqwutl', 'n')
('wmt', 'g')
('aesyhvmw', 'q')
('azfjndwhkqgmtyeb', 'o')

I used random because you don't explain which names of "variables" to give, and which values to create. Because i don't think it's possible to create a name without making it binded to an object.

Use the exec() method. For example, say you have a dictionary and you want to turn each key into a variable with its original dictionary value can do the following.

Python 2

>>> c = {"one": 1, "two": 2}
>>> for k,v in c.iteritems():
...    exec("%s=%s" % (k,v))

>>> one
1
>>> two
2

Python 3

>>> c = {"one": 1, "two": 2}
>>> for k,v in c.items():
...    exec("%s=%s" % (k,v))

>>> one
1
>>> two
2